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Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-upderivative

T. G. YUDINA, Danyang GUO, N. F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA

《化学科学与工程前沿（英文）》 2012年第6卷第2期页码 203-209 doi: 10.1007/s11705-012-1277-2

摘要： Antifungal activity of recombinant medicinal leech destabilase-lysozyme (rec.Dest-Lys) was investigated by using fungi: , and , including yeasts and . Its antibacterial activity was investigated on gram-negative bacteria . These activities were assessed by radial agar diffusion assay, and scanning and transmission electron microscopy. Therefore, destabilase-lysozyme not only is endo-isopeptidase and lysozyme, but also has antifungal and antibacterial activities. Muramidase activity of rec.Dest-Lys disappeared after heat-treating at 90°C for 50 min without the loss of its antimicrobial activity. Furthermore we showed for the first time that the heated-up derivative of rec.Dest-Lys exhibited more potent activities against the above enumerated fungi and gram-negative bacteria than original protein.

关键词： recombinant destabilase-lysozyme (rec.Dest-Lys) antimicrobial activity antifungal activity medicinal leech heated-up derivative of rec.Dest-Lys (T-rec.Dest-Lys)

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Thermal and energy analysis of a Chinese kang

Zhi ZHUANG, Yuguo LI, Xudong YANG, Bin CHEN, Jiaping LIU,

《能源前沿（英文）》 2010年第4卷第1期页码 84-92 doi: 10.1007/s11708-010-0009-x

摘要： About 67million Chinese kangs are still used by about 175million people in China today. The kang utilizes biomass burning for space heating and hence reduces the use of commercial energy. However, the existing design of kangs is largely based on the accumulated experience of craftsmen, for lack of scientific studies and engineering design guidelines. Poor construction of kangs also leads to serious indoor air pollution. In this paper, a macroscopic smoke flow and heat transfer model of an elevated kang is integrated in a widely-used building energy analysis software in China–DeST, and the integrated software can be used for the thermal performance analysis of kang-integrated houses. A typical house with kangs in various villages of northern China is chosen as a case study. The annual performance of the kang under different insulations of building envelope and climatic conditions are discussed. Based on the simulation results, it is found that the thermal comfort requirement of the outside surface of the upper kang plate can be met by a proper construction of the kang and selection of the appropriate firing pattern. The better the insulation of the building envelope is or the better the room air tightness is, the greater the indoor air temperature rise and the greater the building heating load contribution of the kang. In the eight selected cities in northern China, the use of kang can meet 50%–80% of the house heating load.

关键词： Chinese kang elevated kang rural house thermal modeling building energy efficiency DeST

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Synthesis of a cardanol-amine derivative using an ionic liquid catalyst

Alves, Maria T. S. Trevisan, Roseane L. E. da Silva, Roselayne F. Furtado, Zengshe Liu, H. N. Cheng

《化学科学与工程前沿（英文）》 2016年第10卷第3期页码 425-431 doi: 10.1007/s11705-016-1581-3

摘要： Cardanol is a biobased raw material derived from cashew nut shell liquid. In order to extend its utility, new derivatives and additional applications are useful. In this work cardanol was first epoxidized, and a novel aniline derivative prepared from it under mild reaction conditions with the help of an ionic liquid catalyst. The reaction chemistry was studied by using nuclear magnetic resonance. The resulting aminohydrin adduct showed antioxidant property and should also be a useful synthon for further reactions. As an example, the aminohydrin was shown to undergo a condensation reaction with formaldehyde to form a prepolymer, which could be further reacted to form thermosetting resins.

关键词： cardanol epoxidation aminohydrin aniline ionic liquid aniline-formaldehyde

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Numerical study on natural convection in a square enclosure containing a rectangular heated cylinder

Jianhua LU, Zhaoli GUO, Zhenhua CHAI, Baochang SHI,

《能源前沿（英文）》 2009年第3卷第4期页码 373-380 doi: 10.1007/s11708-009-0078-x

摘要： In this paper, the natural convection in a square enclosure with a rectangular heated cylinder is investigated via the lattice Boltzmann method. A detailed study is conducted on the effect of the cylinder width and the Rayleigh number on the fluid flow and heat transfer. The flow structures and heat transfer patterns are classified into eight buoyant regimes, i.e., four steady regimes, two periodic regimes, one multiple periodic regime, and one chaos regime, two of which are reported for the first time.

关键词： natural convection buoyant regime heated cylinder lattice Boltzmann

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多囊卵巢综合征无排卵的胰岛素信号和雄激素合成的新遗传风险和代谢特征 Article

吴效科, 黄志超, 曹义娟, 李建, 李志强, 马红丽, 高敬书, 常惠, 张多加, 丛晶, 王宇, 吴奇, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, 张和平, Richard S. Legro, Ben Willem J. Mol, 师咏勇

《工程（英文）》 2023年第23卷第4期页码 103-111 doi: 10.1016/j.eng.2022.08.013

摘要：研究发现，ZNF438基因中标记为rs2994652 (p=2.47×10^–8)的常见变异和REC114REC114 p.Val101Leu (rs182542888)的PCOS不孕妇女进行促排卵治疗的总排卵率更低（分别为：比值比（OR）=1.96，ZNF438基因的一个常见变异和REC114基因的一个罕见功能突变，以及与二者相关的苯丙氨酸和花生四烯酸代谢物改变，与PCOS女性不孕症的促排卵治疗失败相关。

关键词：多囊卵巢综合征不孕症排卵反应 ZNF438 REC114 全外显子测序深度机器学习

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Thermodynamic models and energy distribution of single-phase heated surface in a boiler under unsteady

Xiyan GUO, Yongping YANG

《能源前沿（英文）》 2011年第5卷第1期页码 69-74 doi: 10.1007/s11708-010-0117-7

摘要： A coal-fired power unit frequently operates under unsteady conditions; thus, in order to acquire scientific energy analysis of the unit, thermodynamic analysis of a single-phase heated surface in a boiler under such conditions requires investigation. Processes are analyzed, and distributions of energy and exergy are qualitatively revealed. Models for energy analysis, entropy analysis, and exergy analysis of control volumes and irreversible heat transfer processes are established. Taking the low-temperature superheater of a 610 t/h-boiler as an example, the distribution of energy, entropy production, and exergy is depicted quantitatively, and the results are analyzed.

关键词： thermodynamic model energy distribution boiler unsteady conditions

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A numerical study of helium-heated inorganic membrane reformer coupling to HTGR

YIN Huaqiang, JIANG Shengyao, JU Huaiming, ZHANG Youjie

《能源前沿（英文）》 2007年第1卷第4期页码 446-450 doi: 10.1007/s11708-007-0065-3

摘要： Based on one-dimensional quasi-homogeneous model, a steady-state model and its computer program were developed for helium-heated inorganic membrane reformer coupling to high temperature gas-cooled reactor (HTGR). The results show

关键词： temperature gas-cooled one-dimensional quasi-homogeneous steady-state helium-heated

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趋化信号接枝的掺镁羟基磷灰石促进间充质干细胞归巢

Alessandro Pistone, Daniela Iannazzo, Claudia Espro, Signorino Galvagno, Anna Tampieri, Monica Montesi, Silvia Panseri, Monica Sandri

《工程（英文）》 2017年第3卷第1期页码 55-59 doi: 10.1016/J.ENG.2017.01.007

摘要：本文以人纤连蛋白片段III1-C(FF III1-C) 及纤连蛋白类似物的肽序列Gly-Arg-Gly-Asp-Ser-Pro-Lys 作为趋化因子，分别共价结合至掺镁羟基磷灰石中，用于研究模拟肽序列接枝的掺镁羟基磷灰石对间充质细胞归巢的调控作用

关键词：掺镁羟基磷灰石间充质干细胞趋化/ 趋触因子骨组织工程

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Chimeric antigen receptor T-cell therapy: a promising treatment modality for relapsed/refractory mantle

Ping Li, Ningxin Dong, Yu Zeng, Jie Liu, Xiaochen Tang, Junbang Wang, Wenjun Zhang, Shiguang Ye, Lili Zhou, Alex Hongsheng Chang, Aibin Liang

《医学前沿（英文）》 2020年第14卷第6期页码 811-815 doi: 10.1007/s11684-020-0740-6

摘要： Mantle cell lymphoma (MCL) is a distinct histological type of B-cell lymphoma with a poor prognosis. Several agents, such as proteasome inhibitors, immunomodulatory drugs, and inhibitors of B cell lymphoma-2 and Bruton’s tyrosine kinase have shown efficacy for relapsed or refractory (r/r) MCL but often have short-term responses. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a novel treatment modality for r/r non-Hodgkin’s lymphoma. However, long-term safety and tolerability associated with CAR T-cell therapy are not defined well, especially in MCL. In this report, we described a 70-year-old patient with r/r MCL with 48-month duration of follow-up who achieved long-term remission after CAR T-cell therapy. CAR T-cell-related toxicities were also mild and tolerated well even in this elderly patient. This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL, who are generally elderly and have comorbid conditions.

关键词： anti-CD19 chimeric antigen receptor T cells mantle cell lymphoma relapsed or refractory long-term follow-up

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OHTMA：面向天河三号E级原型机的一种启发式优化拓扑感知映射算法 Research Articles

李翊谁,陈新海,刘杰,杨博,龚春叶,甘新标,李胜国,徐涵

《信息与电子工程前沿（英文）》 2020年第21卷第6期页码 809-962 doi: 10.1631/FITEE.1900075

摘要：随着应用程序规模和超级计算机体系结构复杂性的迅速增加，拓扑映射的重要性愈加凸显。高通信成本已成为超级计算机上运行的应用程序性能的主要限制因素。为避免不合适的映射策略可能带来的较差通信性能，提出一种启发式优化拓扑感知映射算法（OHTMA）。该算法旨在最小化用于测量映射结果的字节跳跃度量。OHTMA结合贪婪启发式算法和基于对交换的优化方法，减少了远程通信数量，有效增强了通信局部性。在天河三号E级原型机的实验结果表明，OHTMA算法可显著降低通信成本。

关键词：高性能计算；拓扑映射；启发式算法

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Comparisons of bridges flutter derivatives and generalized ones

Fuyou XU , Zhe ZHANG , Cailiang HUANG , Airong CHEN ,

《结构与土木工程前沿（英文）》 2009年第3卷第3期页码 272-278 doi: 10.1007/s11709-009-0042-1

摘要： The causes of the nonlinearity of self-excited aerodynamic force of bridge are interpreted from such two aspects as amplitude and wind velocity. The concept of “generalized flutter derivative” is proposed, and its physical meaning is illustrated. The graphs of the generalized flutter derivatives of plate and Sutong Bridge section model are plotted. The characteristics of all generalized flutter derivatives are compared and analyzed, and their superiorities are verified. The results indicate that the physical meaning of generalized flutter derivatives are more explicit compared to the traditional ones. It is more convenient to understand the nonlinearity properties of self-excited aerodynamic force of bridge according to the generalized flutter derivatives graphs with the wind velocity as the horizontal coordinate.

关键词： bridge flutter derivative generalized flutter derivative self-excited aerodynamic force Sutong Bridge

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Online recognition of drainage type based on UV-vis spectra and derivative neural network algorithm

《环境科学与工程前沿（英文）》 2021年第15卷第6期 doi: 10.1007/s11783-021-1430-6

摘要：

• UV-vis absorption analyzer was applied in drainage type online recognition.

关键词： Drainage online recognition UV-vis spectra Derivative spectrum Convolutional neural network

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Structure controlling and process scale-up in the fabrication of nanomaterials

Chunzhong LI,

《化学科学与工程前沿（英文）》 2010年第4卷第1期页码 18-25 doi: 10.1007/s11705-009-0305-3

摘要： Nanotechnology is already having a significant commercial impact, and will very certainly have a much greater impact in the future. The research on process engineering and scale-up will be very important for the commercial production and application of nanomaterials, because the properties and structure of nanomaterials are not only determined by the nucleation and growth process, but also strongly affected by the engineering properties, such as the mixing, the heat and mass transfer, and also the distribution of temperature, concentration, etc. This paper will present some research work in our laboratory on the fabrication of nanomaterials. Based on the chemical engineering principle and methods, many kinds of novel nanomaterials can be synthesized and their structure can be easily controlled through adjusting the parameters of the fluid mixing, and the distribution of temperature, residence time and concentration, etc. By using the micro-mixing, heat and mass transfer and reaction control methods, the host-guest nanocomposites have been assembled and assumed as the novel electroanalytical sensing nanobiocomposite materials. Based on the principles of chemical engineering, the manufacturing technologies for magnetic powders, calcium carbonate, and titanium dioxide have been developed for commercial-scale production, and the largest production scale has reached 15 kt/year.

关键词： scale-up significant commercial electroanalytical engineering laboratory

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BUEES: a bottom-up event extraction system

Xiao DING,Bing QIN,Ting LIU

《信息与电子工程前沿（英文）》 2015年第16卷第7期页码 541-552 doi: 10.1631/FITEE.1400405

摘要： Traditional event extraction systems focus mainly on event type identification and event participant extraction based on pre-specified event type paradigms and manually annotated corpora. However, different domains have different event type paradigms. When transferring to a new domain, we have to build a new event type paradigm and annotate a new corpus from scratch. This kind of conventional event extraction system requires massive human effort, and hence prevents event extraction from being widely applicable. In this paper, we present BUEES, a bottom-up event extraction system, which extracts events from the web in a completely unsupervised way. The system automatically builds an event type paradigm in the input corpus, and then proceeds to extract a large number of instance patterns of these events. Subsequently, the system extracts event arguments according to these patterns. By conducting a series of experiments, we demonstrate the good performance of BUEES and compare it to a state-of-the-art Chinese event extraction system, i.e., a supervised event extraction system. Experimental results show that BUEES performs comparably (5% higher -measure in event type identification and 3% higher -measure in event argument extraction), but without any human effort.

关键词： Event extraction Unsupervised learning Bottom-up